Intracellular signaling or events are caused on the surfaces of the cells. This signaling is responsible for a myriad of functions ranging from neurotransmission to cytoskeletal organization. What will happen if someone invisible controls your eating habit? The eerie truth is the intracellular signaling in the neural networks of the brain.
Role of Intracellular Signaling in Triggering Cancer
One of the hardships that the oncogenic cells overcome in a jiffy is sustenance of chronic proliferation. To be capable of withstanding the proliferation the mass of the cell must be twice. Hence, they need to amplify the metabolism to support the metabolism synthesis.
Rapidly proliferating cells have their individual requirements. They are different from the cell resting state. Glutamine and glucose are the primary energy sources.
Cancer as Signaling Phenomenon
In humans the intracellular events are complicated. Crosswalks intertwined the phenomenon forming a vast network integrating similar extracellular stimuli for proper cellular responses. Dr. Kanury Rao, the greatest immunologist of all time, has conducted an in-depth analysis of intracellular events to develop a tool for early detection of cancer.
The human network has nodes made of microRNAs and proteins. The general network represents the series of DNA who have a prominent role in expressing the genes. Edges connecting the nodes incorporate the physical network of proteins, DNA- sequence and microRNA.
The DNA sequence includes dephosphorylation and phosphorylation. When cancer develops in the human body, the network inside witnesses the gross changes. The signaling network involved in cancer mainly focuses on triggering the carcinogenic components.
The proteins involved in cancer are the primary agents of signaling networks. When the cancer develops, they boost the regulatory loops. The incorporated data involved in the process are:
- Mono nucleotide
- Epigenetic profiles
In signaling networks, they function the as the specific elements in anti-cancer therapies
There are abundant intracellular interactions among the members of the extremely heterogeneous cancer cells. The major element in cancer evolution is the stomach cells.
The delicate network of inter-cellular signaling has an intricate cooperation type of the involved cells. These cells incessantly grow in the presence of cancer. An ideal example of this is the fibroblast, the changes in the stomach cells where the growth of cancer consequently leads to the formation of cancer.
According to Dr. Kanury Rao, cancer can be prevented from developing into a metastatic stage with the detection devices.
Intercelluar Signaling in the Development and Initiation of Cancer
Tumors evolve because of the high heterogeneous oncogenic cell populations. The stem-like cancer cells display systematic adaptive responses to therapeutic interventions (change in tumor). The characterization of these stem-like cancer cells exhibit the following:
- Rapid proliferation
- Plastic behavior
- Rigid behavior like increased invasiveness, quiescence, asymmetric cell-division
Besides the carcinogenic cells, there are assorted varieties of stromal cells as well:
These cells increase the tumor heterogeneity. Cancer cells along with the surrounding stromal cells make a complicated cellular ecosystem. At the beginning, the mathematical modeling concludes that this intricacy is essential for anti-cancer therapies.
The attribute of the therapies is developing resistance to circumvent drugs. A recent research paper has shown that KRAS (a mutation) has an integral role in developing the reciprocal signaling between stromal fibroblasts and cancer cells. A recent example is the development of mouse breasts and brain metastasis.
The tool that Dr. Kanury Rao developed for detecting cancer is especially for women. They are designed to detect specific cancers like breast cancers, uterus cancers, etc.
Metastatic cells are migratory. They migrate as the community of cells wherein the common interactions take place between the cancer and the stromal cells or only between the cancer cells.
Intercellular Signaling as the Anti-cancer Therapy
Anticancer therapy is mainly associated with the destruction of cancer cells using powerful forces. There are many treatments that adversely affect healthy cells. Incorporation of target treatments may be partially dodging.
However, inhibition of a cancer hallmark will trigger another. This procedure increases metastasis.
Multitarget medications along with combined therapies created especially for intercellular signaling in cancer. They shift the oncogenic attractors in apoptosis. This analysis may also be applied for the signaling networks of the stromal or cancer cell ecosystem.
The best example of this intervention is the hampering of proliferation pathways. As an alternative, therapies or target treatments including therapies or stromal cells are also offering novel inventions.
The dynamic observation of the patient-disease relation is the new aspect that has led to the multiple domains of anticancer inventions.
It is a vital system through which the cell communicates and reacts to their surroundings. The abnormal intercellular signaling networks trigger the proliferation of cells. Dr. Kanury Rao, with an immense analysis developed a state-of-the-art tool to detect such abnormal cellular communication in an early stage. The early detection will prevent fatalities.